Ropinirole (SK and F 101468) in the treatment of Parkinson's disease.
نویسندگان
چکیده
do not persist for more than three weeks.4 Likewise, there was no evidence of haemosiderin deposition in the stalk which might be expected after haemorrhage. Stalk enlargement could have been an effect of untreated diabetes insipidus, in which the first case might have expected resolution of the abnormality with treatment. However, the swelling persisted for three months despite adequate treatment of the diabetes insipidus. It is possible that unrecognised injury or infection with ensuing inflammation resulted in the swelling observed initially. It is known that insults to the stalk can lead to reorganisa-tion and proximal enlargement.' We may have observed the resolution ofsuch changes. We conclude that pituitary stalk enlargement may occur in idiopathic cranial diabetes insipidus, persist for months, and eventually disappear. Serial imaging with CT or MRI will exclude progressive infiltrative or neoplastic causes. Transection of the pituitary stalk: Development ofan ectopic posterior lobe assessed with MR imaging. Ropinirole
منابع مشابه
Ropinirole therapy for Parkinson's disease.
Ropinirole (Requip, GlaxoSmithKline) is a novel nonergoline dopamine D2 agonist indicated for the treatment of early and advanced Parkinson's disease. It is mainly metabolized by the liver and its elimination half-life is approximately 5.8 h. When used as monotherapy in early Parkinson's disease, ropinirole improves signs and symptoms of the disorder. When used as an adjunct to levodopa in adva...
متن کاملAre Branded and Generic Extended-Release Ropinirole Formulations Equally Efficacious? A Rater-Blinded, Switch-Over, Multicenter Study
The aim of this study was to compare the efficacy of the branded and a generic extended-release ropinirole formulation in the treatment of advanced Parkinson's disease (PD). Of 22 enrolled patients 21 completed the study. A rater blinded to treatment evaluated Unified Parkinson's Disease Rating Scale, Fahn-Tolosa-Marin Tremor Rating Scale, Nonmotor Symptoms Assessment Scale, and a structured qu...
متن کاملUpdate on ropinirole in the treatment of Parkinson’s disease
Ropinirole is a dopamine agonist, approved for use to treat symptoms of early and advanced Parkinson's disease, is now available in a 24-hour formulation in addition to the immediate release version. This review discusses the mode of action of ropinirole and compares the pharmacokinetics of both formulations. Pivotal studies leading to the approval of both preparations are reviewed in terms of ...
متن کاملNonergot dopamine-receptor agonists for treating Parkinson’s disease – a network meta-analysis
OBJECTIVE To compare the efficacy of the three nonergot dopamine-receptor agonists (DAs) pramipexole, ropinirole, and rotigotine for the treatment of early and advanced Parkinson's disease (PD). MATERIALS AND METHODS Bayesian network meta-analyses were performed separately for early and advanced PD, and at time points 11-16 and 24-28 weeks. Outcomes for early PD included improvement on the Un...
متن کاملA five-year study of the incidence of dyskinesia in patients with early Parkinson's disease who were treated with ropinirole or levodopa.
BACKGROUND There is debate about whether the initial treatment for patients with Parkinson's disease should be levodopa or a dopamine agonist. METHODS In this prospective, randomized, double-blind study, we compared the safety and efficacy of the dopamine D2-receptor agonist ropinirole with that of levodopa over a period of five years in 268 patients with early Parkinson's disease. If symptom...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 54 10 شماره
صفحات -
تاریخ انتشار 1991